' 
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.3
USERS' SCORE
Good
Based on 26 Reviews
8.6
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Niacin (Vitamin B-3)(from 640 mg of Inositol Hexanicotinate)
500 mg
3125%
Inositol (from 640 mg of Inositol Hexanicotinate)
135 mg
†
Top Medical Research Studies
8
Inositol boosts heart protective adiponectin
Depleting inositol pyrophosphate 5-InsP7 protected the heart against ischaemia-reperfusion injury by elevating plasma adiponectin.
High relevance to heart disease treatment.
Our research focused on understanding how inositol, specifically a molecule called 5-InsP7, plays a role in heart health by influencing levels of a substance called adiponectin. Adiponectin is important because it helps protect against cardiovascular issues and metabolic disorders.
We discovered that the enzyme inositol hexakisphosphate kinase 1 (IP6K1) produces 5-InsP7, which helps regulate how much adiponectin is available in the bloodstream. This regulation occurs through a process that ensures adiponectin stays stable instead of degrading within the cells.
When we decreased the levels of 5-InsP7—either by knocking out the gene responsible for producing it or through specific drug treatments—we noticed a significant increase in adiponectin levels in the plasma. This increase particularly favored the high molecular weight forms of adiponectin, which are particularly beneficial for heart protection.
The findings suggest that targeting 5-InsP7 could be a promising strategy for enhancing adiponectin levels, potentially offering a new avenue for protecting the heart against damage from conditions like ischemia-reperfusion injury, which occurs when blood flow returns to the heart after a period of blockage.
Overall, this study gives insight into how inositol treatment might help heart disease, emphasizing the importance of adiponectin in cardiovascular health.
We discovered that the enzyme inositol hexakisphosphate kinase 1 (IP6K1) produces 5-InsP7, which helps regulate how much adiponectin is available in the bloodstream. This regulation occurs through a process that ensures adiponectin stays stable instead of degrading within the cells.
When we decreased the levels of 5-InsP7—either by knocking out the gene responsible for producing it or through specific drug treatments—we noticed a significant increase in adiponectin levels in the plasma. This increase particularly favored the high molecular weight forms of adiponectin, which are particularly beneficial for heart protection.
The findings suggest that targeting 5-InsP7 could be a promising strategy for enhancing adiponectin levels, potentially offering a new avenue for protecting the heart against damage from conditions like ischemia-reperfusion injury, which occurs when blood flow returns to the heart after a period of blockage.
Overall, this study gives insight into how inositol treatment might help heart disease, emphasizing the importance of adiponectin in cardiovascular health.
Read More
9
Inositol counters lithium heart damage
Oral supplementation of inositols effectively recovered lithium-induced cardiac dysfunctions in mice.
Directly explores inositol effects
Our study aimed to understand how inositol supplementation could help combat heart issues caused by lithium in mice. We examined four groups of C57BL6 mice, some of which received lithium for eight weeks, while others either received inositol during or after the lithium treatment. We specifically looked at various heart functions, structures, and how the heart cells responded to stress.
We found that inositol has a significant protective effect on the heart. Mice that received inositol, either during or after lithium exposure, showed improvements in heart size, function, and electrical stability. For example, the inositol group had reduced heart cell swelling and better performance during stress tests. Overall, these findings suggest that inositol could serve as a beneficial strategy for managing lithium-induced cardiac issues.
Furthermore, the inositol treatment appeared to reverse changes associated with heart muscle enlargement and helped stabilize the expression of certain proteins critical for heart function. In contrast, untreated mice displayed increased cardiac dysfunction and other organ issues. Overall, the study underscores inositol's promise as a potential treatment for heart-related side effects arising from lithium use.
We found that inositol has a significant protective effect on the heart. Mice that received inositol, either during or after lithium exposure, showed improvements in heart size, function, and electrical stability. For example, the inositol group had reduced heart cell swelling and better performance during stress tests. Overall, these findings suggest that inositol could serve as a beneficial strategy for managing lithium-induced cardiac issues.
Furthermore, the inositol treatment appeared to reverse changes associated with heart muscle enlargement and helped stabilize the expression of certain proteins critical for heart function. In contrast, untreated mice displayed increased cardiac dysfunction and other organ issues. Overall, the study underscores inositol's promise as a potential treatment for heart-related side effects arising from lithium use.
Read More
8
ITPP shows promise in heart health
Myo-inositol trispyrophosphate prevents right ventricular failure and improves survival in monocrotaline-induced pulmonary hypertension in the rat.
Strong relevance to heart disease
We explored the effects of myo-inositol trispyrophosphate (ITPP) on heart disease, particularly in the context of pulmonary hypertension (PH). The study involved injecting rats with monocrotaline, which induces PH, and then administering either ITPP or a placebo over five weeks. Through careful monitoring techniques, including echocardiograms and pressure-volume loops, we aimed to see whether ITPP could alleviate the negative impacts of PH on the heart.
Our findings revealed that ITPP indeed reduced mortality associated with PH. While it didn't change the rise in pulmonary vascular resistance, it significantly improved heart function by relieving hypoxia in the right ventricle (RV). This relief was tied to a decrease in RV wall stress, enhancing the heart’s ability to pump effectively under strain. Additionally, we noted that ITPP may help prevent some changes associated with oxygen deprivation, although it did not affect capillary density in the heart.
The implications of our research suggest that enhancing oxygen delivery to the right ventricle could be a valuable addition to existing treatments for PH. ITPP stands out as a promising candidate that could help the heart better manage the increased pressure it faces in these conditions, ultimately improving survival rates.
Our findings revealed that ITPP indeed reduced mortality associated with PH. While it didn't change the rise in pulmonary vascular resistance, it significantly improved heart function by relieving hypoxia in the right ventricle (RV). This relief was tied to a decrease in RV wall stress, enhancing the heart’s ability to pump effectively under strain. Additionally, we noted that ITPP may help prevent some changes associated with oxygen deprivation, although it did not affect capillary density in the heart.
The implications of our research suggest that enhancing oxygen delivery to the right ventricle could be a valuable addition to existing treatments for PH. ITPP stands out as a promising candidate that could help the heart better manage the increased pressure it faces in these conditions, ultimately improving survival rates.
Read More
Most Useful Reviews
9.5
Helps with circulation
Niacin is effective for high cholesterol and aids in circulation issues, migraines, and digestive problems. It also assists those seeking to pass drug tests. Niacinamide treats diabetes and skin conditions. It's beneficial for schizophrenia, memory issues, and heart disease, making it a versatile and valuable supplement.
Read More
9.5
Good for heart and energy
This Now Flush-Free Niacin is of high quality, easy to swallow, and enhances energy levels. It effectively supports heart health and lowers triglycerides without an aftertaste.
Read More
9.5
Supports heart health
Niacin, or Vitamin B3, is vital for energy production, nervous system support, cholesterol metabolism, liver detoxification, and heart protection.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.3
- All Researches
9
Inositol counters lithium heart damage
Oral supplementation of inositols effectively recovered lithium-induced cardiac dysfunctions in mice.
Directly explores inositol effects
Our study aimed to understand how inositol supplementation could help combat heart issues caused by lithium in mice. We examined four groups of C57BL6 mice, some of which received lithium for eight weeks, while others either received inositol during or after the lithium treatment. We specifically looked at various heart functions, structures, and how the heart cells responded to stress.
We found that inositol has a significant protective effect on the heart. Mice that received inositol, either during or after lithium exposure, showed improvements in heart size, function, and electrical stability. For example, the inositol group had reduced heart cell swelling and better performance during stress tests. Overall, these findings suggest that inositol could serve as a beneficial strategy for managing lithium-induced cardiac issues.
Furthermore, the inositol treatment appeared to reverse changes associated with heart muscle enlargement and helped stabilize the expression of certain proteins critical for heart function. In contrast, untreated mice displayed increased cardiac dysfunction and other organ issues. Overall, the study underscores inositol's promise as a potential treatment for heart-related side effects arising from lithium use.
We found that inositol has a significant protective effect on the heart. Mice that received inositol, either during or after lithium exposure, showed improvements in heart size, function, and electrical stability. For example, the inositol group had reduced heart cell swelling and better performance during stress tests. Overall, these findings suggest that inositol could serve as a beneficial strategy for managing lithium-induced cardiac issues.
Furthermore, the inositol treatment appeared to reverse changes associated with heart muscle enlargement and helped stabilize the expression of certain proteins critical for heart function. In contrast, untreated mice displayed increased cardiac dysfunction and other organ issues. Overall, the study underscores inositol's promise as a potential treatment for heart-related side effects arising from lithium use.
Read More
8
ITPP shows promise in heart health
Myo-inositol trispyrophosphate prevents right ventricular failure and improves survival in monocrotaline-induced pulmonary hypertension in the rat.
Strong relevance to heart disease
We explored the effects of myo-inositol trispyrophosphate (ITPP) on heart disease, particularly in the context of pulmonary hypertension (PH). The study involved injecting rats with monocrotaline, which induces PH, and then administering either ITPP or a placebo over five weeks. Through careful monitoring techniques, including echocardiograms and pressure-volume loops, we aimed to see whether ITPP could alleviate the negative impacts of PH on the heart.
Our findings revealed that ITPP indeed reduced mortality associated with PH. While it didn't change the rise in pulmonary vascular resistance, it significantly improved heart function by relieving hypoxia in the right ventricle (RV). This relief was tied to a decrease in RV wall stress, enhancing the heart’s ability to pump effectively under strain. Additionally, we noted that ITPP may help prevent some changes associated with oxygen deprivation, although it did not affect capillary density in the heart.
The implications of our research suggest that enhancing oxygen delivery to the right ventricle could be a valuable addition to existing treatments for PH. ITPP stands out as a promising candidate that could help the heart better manage the increased pressure it faces in these conditions, ultimately improving survival rates.
Our findings revealed that ITPP indeed reduced mortality associated with PH. While it didn't change the rise in pulmonary vascular resistance, it significantly improved heart function by relieving hypoxia in the right ventricle (RV). This relief was tied to a decrease in RV wall stress, enhancing the heart’s ability to pump effectively under strain. Additionally, we noted that ITPP may help prevent some changes associated with oxygen deprivation, although it did not affect capillary density in the heart.
The implications of our research suggest that enhancing oxygen delivery to the right ventricle could be a valuable addition to existing treatments for PH. ITPP stands out as a promising candidate that could help the heart better manage the increased pressure it faces in these conditions, ultimately improving survival rates.
Read More
8
Inositol boosts heart protective adiponectin
Depleting inositol pyrophosphate 5-InsP7 protected the heart against ischaemia-reperfusion injury by elevating plasma adiponectin.
High relevance to heart disease treatment.
Our research focused on understanding how inositol, specifically a molecule called 5-InsP7, plays a role in heart health by influencing levels of a substance called adiponectin. Adiponectin is important because it helps protect against cardiovascular issues and metabolic disorders.
We discovered that the enzyme inositol hexakisphosphate kinase 1 (IP6K1) produces 5-InsP7, which helps regulate how much adiponectin is available in the bloodstream. This regulation occurs through a process that ensures adiponectin stays stable instead of degrading within the cells.
When we decreased the levels of 5-InsP7—either by knocking out the gene responsible for producing it or through specific drug treatments—we noticed a significant increase in adiponectin levels in the plasma. This increase particularly favored the high molecular weight forms of adiponectin, which are particularly beneficial for heart protection.
The findings suggest that targeting 5-InsP7 could be a promising strategy for enhancing adiponectin levels, potentially offering a new avenue for protecting the heart against damage from conditions like ischemia-reperfusion injury, which occurs when blood flow returns to the heart after a period of blockage.
Overall, this study gives insight into how inositol treatment might help heart disease, emphasizing the importance of adiponectin in cardiovascular health.
We discovered that the enzyme inositol hexakisphosphate kinase 1 (IP6K1) produces 5-InsP7, which helps regulate how much adiponectin is available in the bloodstream. This regulation occurs through a process that ensures adiponectin stays stable instead of degrading within the cells.
When we decreased the levels of 5-InsP7—either by knocking out the gene responsible for producing it or through specific drug treatments—we noticed a significant increase in adiponectin levels in the plasma. This increase particularly favored the high molecular weight forms of adiponectin, which are particularly beneficial for heart protection.
The findings suggest that targeting 5-InsP7 could be a promising strategy for enhancing adiponectin levels, potentially offering a new avenue for protecting the heart against damage from conditions like ischemia-reperfusion injury, which occurs when blood flow returns to the heart after a period of blockage.
Overall, this study gives insight into how inositol treatment might help heart disease, emphasizing the importance of adiponectin in cardiovascular health.
Read More
User Reviews
USERS' SCORE
Good
Based on 26 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Helps with circulation
Niacin is effective for high cholesterol and aids in circulation issues, migraines, and digestive problems. It also assists those seeking to pass drug tests. Niacinamide treats diabetes and skin conditions. It's beneficial for schizophrenia, memory issues, and heart disease, making it a versatile and valuable supplement.
Read More
9.5
Good for heart and energy
This Now Flush-Free Niacin is of high quality, easy to swallow, and enhances energy levels. It effectively supports heart health and lowers triglycerides without an aftertaste.
9.5
Supports heart health
Niacin, or Vitamin B3, is vital for energy production, nervous system support, cholesterol metabolism, liver detoxification, and heart protection.
9.5
Clears blood vessels
I have coronary heart disease with significant blockages. Niacin helps clear blood vessels effectively, and I have noticed reduced side effects. I trust its high-quality ingredients don't affect my allergies.
9
Supports heart health
Niacin, a crucial B vitamin, aids energy production. This form avoids unpleasant flushing, boosts circulation, heart health, and helps maintain a balanced lipid profile, reducing fatigue and depression.
